A novel combination of organic acids helps poultry producers realize superior levels of gut health and performance

T在这里 are a number of ways to boost gut health including making improvements to flock management and litter management, 并确保提供新鲜清洁的饮用水. Feed additives are a useful tool to support the birds’ intrinsic nutritional requirements. Short chain fatty acids (SCFAs) are typically present in the gastrointestinal tract as a product of the fermentation of non-digestible carbohydrates, 氨基酸, 和蛋白质. Including additional SCFAs in the diet delivers a range of gut health and performance benefits for broilers including:

• 改善饲料卫生
• 胃酸化增加
• 更好的病原体控制
• 免疫反应的调节
• 改善肠道形态和粘膜生成
  
  

丁酸能改善肠道健康

Butyric acid is accepted as a SCFA that plays a crucial role in gut health. T在这里 is a library of scientific information available which supports the role of butyric acid in improving animal performance due to its positive effect in the gut. 布莱克等人. (2020)将行动方式描述为:

1. Directly impacting the epithelial function by providing energy to epithelial cells, 辅助电解质输送, 调节pH值
2. Promoting mucus production and hence supporting the stability of the barrier between epithelial cells and the outside
3. Impacting the intestinal barrier function by supporting epithelial cell integrity, 减少磁导率, 促进紧密连接表达
4. 积极影响粘膜免疫功能
5. Inducing expression of antimicrobial proteins (defensins and cathelicidins)
6. Affecting the enteric nervous system with an apparent impact on the motility of the epithelial cells

尽管丁酸的作用是公认的, 科学研究仍在继续，以进一步加深我们的认识. That research has led to the recent discovery of the importance of valeric acid. 

戊酸:有机酸之谜的最新发现

戊 acid is gaining attention in a number of fields, including human medicine. Various in vitro and in vivo studies (in mice) have shown that valeric acid is capable of preventing inflammation and maintaining gut integrity. 作为组蛋白去乙酰化酶抑制剂(HDI)的特性, 用于精神病学和神经学, 在治疗癌症方面的应用是否吸引了更多的关注, 寄生虫感染和炎症性疾病. 

在家禽生产中, valeric acid (in its esterified form) has shown to have a positive effect on the intestinal structure of broilers by increasing the production of GLP-2, a peptide which is considered to have an important role in promoting intestinal growth and function. Another study reported a reduction in lesion scoring and mortality after a Clostridium perfringens challenge when valeric acid was included in the diet. So, what happens to broiler performance when you combine butyric acid with valeric acid in the feed?

用戊酸发现肉鸡生产性能的新水平

A study was conducted to evaluate the effects of the combination of butyric acid and valeric acid (Gastrivix™Avi, 对肉鸡生长性能的影响. 试验是在家禽管理研究所进行的 & 技术在印度和使用3250孵化, day-old Vencobb 430Y chicks divided into four dietary treatment groups (with eight replicates/treatment and 110 birds/replicate). 治疗方法见表1. Feed refusal and body weight were measured weekly until the end of the trial (day 42). 第4天, 28和42, one bird per replicate (eight birds in total) was randomly selected from each pen and euthanized for jejunum and ileum morphology analysis. 结果如表2所示.

表1. 治疗概述

表2. Comparison of performance parameters and jejunum and ileum villi length and crypt depth in broilers fed different dietary treatments

(来源:Li et al .. 澳大利亚家禽科学研讨会(2023)

The results of the trial show that performance in the broilers fed a diet containing a combination of butyric and valeric acid (T3) was at least as good, 如果对某些参数不是更好的话, as the performance of the broilers fed diets containing the antibiotic Bacitracin Methylene Disalicylate (BMD; T2). 在两组中, feed conversion rate (货物收据) was improved by 6 points compared to the control group (T1). 体增重(BWG)为0.BMD组1 kg, BMD组0.丁酸/戊酸组有18公斤, 与对照组相比，两者都有显著改善. 

Broilers fed the diet containing butyric and valeric acid in addition to in-feed BMD showed further improvements in growth performance and feed efficiency over and above the BMD treatment alone, 货物收据提高了11个点，BWG提高了0.27 kg. These improvements are the result of the improved gut morphology in the small intestine which increases nutrient absorption efficacy.

一种新的有机酸组合提供了更多的性能

Continuing to investigate the role played by organic acids in poultry diets has uncovered a new piece of the puzzle. Poultry producers can now include a novel combination of butyric and valeric acid in their diets, 不管有没有抗生素, and realize even better performance from their flock due to the improvements in gut morphology. The intestinal growth effects of butyric acid and the anti-inflammatory benefits of valeric acid support the animals ability to better use the fed energy to grow. 

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